Last update : 01/02/2011 - Release 36
Genbank access number : NG_008832.1

Abnormality  
Plasma protein N-19 Native protein N Gene
(as reported) 		e-i Gene status Name / Origin Type Haemorraghes Thromboses Authours  
   
g.773 : 4.1 kb del
   compound P1 ITALY  = F5 FLORENCE a
Yes
       Monaldini L et al. 2007      
      -1138 C T       HAMAMATSU h     Okumara N et al. 2000  A
Aα(-18)
frameshift stop		     34insC       BELGIUM A8 a     Neerman-Arbez M et al. 2000  
Aα(-2)                            
 
    11 kb deletion       GENEVA a     Neerman-Arbez M et al. 1999  
 
       11 kb deletion       FRANCE A3 a           Neerman-Arbez M et al. 2001     
 
       11 kb deletion       FRANCE C5  a            Neerman-Arbez M et al. 2001     
    11 kb deletion   compound KINGSPORT a           Galanakis DK et al. 2007    
 
       11 kb deletion       SWITZERLAND B6 a           Neerman-Arbez M et al. 2001     
 
       11 kb deletion       SWITZERLAND B7 a           Neerman-Arbez M et al. 2001     
 
       11 kb deletion       SWITZERLAND C3 a           Neerman-Arbez M et al. 2001     
 
    11 kb deletion       UNITED STATES B4 a     Neerman-Arbez M et al. 2000  
 
    IVS1+1G A       R99 a  Yes  (No) Monaldini L et al. 2005  
 
    IVS1+3A G       FRANCE A10 a     Neerman-Arbez M et al. 2000  
Aα(-1)                              
Aα(7)AspAsn           LILLE      No No Morris S et al. 1981 A
Aα(8)PheCys       T G                 No No Mumford AD et al.2001 A
Aα(9)      g.1185de1T       FRANCE A3 a       Neerman-Arbez M et al. 2001  
Aα(9)LeuPro      1182TC       MAGDEBURG  
No
No
Meyer M et al. 2003  
Aα(11)GluGly           MITAKA II      Yes No Meyer M et al. 2003  
"   A G                     Meyer M et al. 2000 A
Aα(12)GlyVal           ROUEN      Yes No Henschen A et al. 1983 L
"   G T       SAINT GERMAIN   No No Mathonnet F et al. 2002  
Aα(13)GlyStop   1193G T  
compound
 P1 ITALY = F5 FLORENCE a Yes No Asselta R et al. 2001  
Aα(13)GlyGlu           HANNOVER XXV       Czwalinna A 2004 O
Aα(15)ValGlu   T A                   Meyer M et al. 2000 A
Aα(16)ArgCys           AMSTERDAM      No No Henschen A et al. 1984  
"           BERGAMO      No No Reber P et al. 1985  
"           BERN III      No No Furlan M et al. 1991  
"           BERN V      Yes No Stücki B et al. 1999  
"   CGTTGT       BRAUNSCHWEIG      No Yes Meyer M et al. 2000 A
"   CGTTGT       ERFURT      No No Meyer M et al. 2000 A
"   CGTTGT       ERLANGEN      Yes No Meyer M et al. 2000 A
"   CGTTGT       ERLANGEN II      No No Meyer M et al. 2000 A
"   CGTTGT       ERLANGEN III      Yes No Meyer M et al. 2000 A
"   CGTTGT       ERLANGEN IV      No Yes Meyer M et al. 2000 A
"           FRANKFURT II      Yes No Henschen A et al. 1984  
"           FRANKFURT III      Yes No Henschen A et al. 1984  
"           FRANKFURT V      No Yes Haverkate F et al. 1995  
"       heterozyg FRANKFURT VI (n=3)      - - Miesbach W et al. 2009  
"       heterozyg FRANKFURT X (n=3)      Yes   Miesbach W et al. 2009  
"       heterozyg FRANKFURT XII (n=2)      Yes   Miesbach W et al. 2009  
"       heterozyg FRANKFURT XIII      No No Galanakis D et al. 1993  
"       homozyg FRANKFURT XIII (n=2)      Yes Yes Miesbach W et al. 2009  
"       heterozyg FRANKFURT XVI (n=3)      Yes   Miesbach W et al. 2009  
"       
compound
 FREIBURG           Czwalinna A 2004  O
"           GENEVA      No No Furlan M et al. 1990  
"   CGTTGT       GIESSEN IV      Yes No Meyer M et al. 2000 A
"   CGTTGT       HANNOVER III      No No Meyer M et al. 2000 A
"   CGTTGT          HANNOVER VIII                Czwalinna Aet al. 2001 A
"            HANNOVER XXVIII                   Czwalinna A 2004 O
"   CGTTGT          HERSHEY II      No Yes Galanakis D K et al. 1990 L
"   CGTTGT       HERSHEY III      Yes   Flood VH et al. 2006  
"           HOMBURG II      No No Miyashita C et al. 1985 L
"              HOMBURG III      Yes No Miyashita C et al. 1985 L
"   CGTTGT       JENA      No No Meyer M et al. 2000 A
"   1202CT          KAISERSLAUTERN III      Yes No Loreth RM et al.2001 A
"           KAWAGUCHI      No No Matsuda M et al. 1986 L
"           LEDYARD      Yes No Lee M H et al. 1991  
"   CGTTGT          LEOGAN      No No Galanakis D K et al. 1990 L
"           LONDON III      No No Lane D et al. 1987  
"           LONDON VI          Lane D et al. 1987  
"              METZ      Yes No Soria J et al. 1982 L
"   1202CT       MILANO XII   No No Bolliger-Stucki B et al. 2001  
"  
CT
       NORTHSPRING       
Yes 2
Galanakis D et al. 2003 A
"       heterozyg NOVY JICIN   Yes   Kotlin R et al. 2007  
"           OSAKA      No No Matsuda M et al. 1986 L
"   3455CT   heterozyg OSTRAVA II   No No Kotlin R et al. 2010  
"           OVIADO II ou MADRID II      No No Lane D et al. 1987  
"           SCHWARZACH      No No Henschen A et al. 1983 L
"           STONY BROOK      No No Galanakis D et al. 1989  
"           TORINO      No No Reber P et al. 1987  
"           ZÜRICH      No No Henschen A et al. 1983 L
Aα(16)ArgHis
           AMIENS          Soria J et al. 1987 L
"           AMIENS II            Soria J et al. 1987  
"           BARCELONA II      Yes No Borrel M et al. 1990   
"           BERGAMO III      No No Reber P et al. 1987  
"           BERN II      No No Rupp C et al. 1983  
"           BERN IV      No No Stücki B et al. 1999  
"           BICÊTRE          Henschen A et al. 1983 L
"           BIRMINGHAM      Yes No Siebenlist K R et al. 1988  
"           CHAPEL HILL II      Yes No Carrell N et al. 1985 L
"   CGTCAT       KAISERSLAUTERN II      Yes No Loreth R M et al. 1997 A
"           CLERMONT-FERRAND          Soria J et al. 1985 L
"           GIESSEN      Yes No Alving B M et al. 1987  
"              KENDAL          Lane D A et al. 1987 L
"           KIEL      No No Seydewitz H H et al. 1991  
"   GA   compound KINGSPORT       Galanakis DK et al. 2007  
"           LEITCHFIELD          Henschen A et al. 1984 L
"           (LONDON)     
No
No
 Mitchell M et al. 2002
A
"            LONDON VII             Lane D et al. 1987  
"           LONG BEACH          Pirkle H et al. 1987 A
"           LOUISVILLE      Yes No Galanakis D K et al. 1983  
"    CGTCAT       LÜBECK      No No Meyer M et al. 2000 A
"   CGTCAT       MANCHESTER      No No Southan C et al. 1983  
"           MILANO IV      No No Bögli C et al. 1992  
"           MILANO VI      Yes No Bögli C et al. 1990  
"           MILANO XI      No No Stücki B et al. 1999  
"           NEW ALBANY      No No Henschen A et al. 1983 L
"   CGTCAT       NEW BRITAIN      No No Webb C D et al. 1994  
"           OSAKA IV      No No Yamazumi K et al. 1993  
"   3456GA   heterozyg OSTRAVA   No No Kotlin R et al. 2010  
"           PARIS VI          Southan C et al. 1987  
"           PETOSKEY      No No Higgins D L et al. 1981  
"   CGTCAT       POISSY      No Yes 1 Mathonnet F et al 1997  
"   CGTCAT       POISSY III          Mathonnet F et al 2001  
"       heterozyg PRAHA II          Kotlin R et al. 2007   
"           SAPPORO      No No Asakura S et al. 1989  
"              SEATTLE II      No No Ebert R F et al. 1986  
"           SHEFFIELD      Yes No Southan C et al. 1987  
"           STONY BROOK II      Yes No Galanakis D K et al. 1990  
"           SYDNEY      No No Southan C et al. 1985 L
"           SYDNEY II          Southan C et al. 1985 L
"   CGTCAT       TAHITI       
    
 Mathonnet F et al 2001  
"           WHITE MARSH          Carr M E et al. 1987  
Aα(16)ArgSer       heterozyg FRANKFURT XI          Miesbach W et al. 2009  
Aα(17)GlyVal           BREMEN      Yes No Wada Y et al. 1993  
Aα(18)ProLeu           KANAZAWA      No No Uotani C et al. 1990  
"           KYOTO II      Yes No Yoshida N et al. 1991  
Aα(19)ArgSer           DETROIT      Yes No Blombäck M et al. 1968  
Aα(19)ArgAsn           MUNICH      Yes No Henschen A et al. 1983 L
Aα(19)ArgGly           AARHUS      No Yes Blömback B et al. 1988 L
"           KUMAMOTO      No Yes Yamaguchi F I et al.1996 A
"           MANNHEIM      Yes No Dempfle C E H et al. 1990 L
"   AGGGGG       MATSUMOTO V      No No Tanaka H et al. 2001  
"   AGGGGG       MILANO XIII      Yes No Bolliger-Stücki B et al. 1999  
"   AGGGGG       OSLO IV      No No Brennan S O et al. 1997   
Aα(20)ValAsp   GTTGAT       CANTERBURY      Yes No Brennan S O et al. 1995   
Aα(20)Val
frameshiftStop		   1215delT   compound R3 ROME a Yes No Asselta R et al. 2001   
"   1215delT  
compound
 GEELONG a Yes No Saravanan L et al. 2008   
Aα(21)Val
frameshift stop
Val40TrpfsX31
 g.1215delT  
compound
 P2 ITALY (Palermo) a Yes   Monaldini L et al. 2007   
Aα(41)                             
    
IVS2+1G>C
 
heterozyg
 CHINESE h No No Chen H et al. 2008  
    
IVS2+1G>T
 
heterozyg
 FREIBURG II h     Czwalinna A 2004  O
    
c.180+2T>C
  
heterozyg
 POLAND h
Yes
   Neerman-Arbez M et al. 2007  
    
IVS2+3insCAT
  
heterozyg
 Montpellier II (3 cases) hd
Yes
 Yes Vorjohann S et al. 2010  
Aα(42)                       
Aα(45)CysPhe    g.1749G>T   heterozyg CREMONA h  No No  Platè M et al. 2008  
Aα(47)Ser-
frameshift-stop		    1754-1755insT       R76 a  Yes No  Monaldini L et al 2005  
Aα(51)ArgMet   1767TG   compound ROME a     Platé M et al. 2007  
Aα(58)Val
ProLeuMet stop		 Val77delins ProLeuMetX     g.1787_1789del3ins12  
homozyg 
 P6 IRAN (Shiraz) a  Yes   Monaldini L et al. 2007  
Aα(69)Leu His L88H TA e3
heterozyg 
 SAN DIEGO IV      Yes Morris TA et al. 2009  
Aα(76)Tyr stop Y95X            LEBANON C6 a     Neerman-Arbez M et al. 2001   
A α (80) Asn del      1852-1854del       CARACAS VI      Yes Yes Marchi RC et al. 2004    
Aα(100) Serstop   1914CG  
homozyg
 I3 IRAN a Yes No Asselta R et al. 2001  
Aα(102)                       
 
   2008 to 3245 deleted         a
Yes
No
Watanabe K et al. 2003  
 
   IVS3+1_+4del       USA B12 a     Neerman-Arbez M et al. 2001  
 
    IVS3+1_+4del       TURKEY C1 a     Neerman-Arbez M et al. 2001   
 
    IVS3+1_+4del   homozyg IRAQUI, 2 cases a Yes No Erlacher M et al. 2009   
 
   
g.1892-1899del
  
compound
 SHANGHAI
a
     Fang Y et al. 2003  
 
   
g.1878-3215del
  
compound
 SHANGHAI
a
     Fang Y et al. 2003  
Aα(103)                       
Aα(106)AsnAsp    5324 AG e4 heterozyg PLZEN   No Yes Kotlín R et al. 2009  
Aα(110)Argstop    3075CT  
homozyg
 P4 PALERMO a No Yes Asselta R et al. 2001  
"    3075CT  
homozyg
 B1 BARBADOS a Yes No Asselta R et al. 2001  
"
Arg129X
 g.3075C T  
homozyg
 P4 INDIA (Mumbai) a Yes   Monaldini L et al. 2007  
Aα(125)
frameshift stop		   3120-3122delAA       DUTCH a
Yes
No
Remijn JA et al. 2003  
"   3121delAA       BELGIUM A8 a     Neerman-Arbez M et al. 2000  
"   3121delAA       FRANCE A12 a     Neerman-Arbez M et al. 2000  
Aα(131) Glnstop
Q150X
3108CT
  
homozyg
 SUSHOU
a
Yes
No
 Wu S et al. 2005  
Aα(141)ArgSer           LIMA      Yes No Maekawa H et al. 1992   
Aα(149)Arg Stop R168X CGATGA       FRANCE B9 a     Neerman-Arbez M et al. 2001   
"   CGATGA       NORWEGIAN / BAFFIN BAY a Yes No Fellowes AP et al. 2000  
"   3192CT  
homozyg
 C9 CAGLIARI a Yes No Asselta R et al. 2001  
"   3192CT  
homozyg
 S2 SASSARI a Yes No Asselta R et al. 2001  
"   3192CT  
homozyg
 S3 SASSARI a Yes No Asselta R et al. 2001  
Aα(151)                                                   
 
   IVS4+1 G T   compound FRANCE a Yes   Angles-Cano E et al. 2007  
   
15 kb deletion
  
isodisomy
 THAI a Yes Yes Spena S et al. 2004  
 
   IVS4+1 G T       BELGIUM A9 a     Neerman-Arbez M et al. 2000  
 
   IVS4+1 G T       FRANCE A2 a     Neerman-Arbez M et al. 2000  
 
   IVS4+1 G T       FRANCE A5 a     Neerman-Arbez M et al. 2000  
 
   IVS4+1 G T       FRANCE A6 a     Neerman-Arbez M et al. 2000  
 
   IVS4+1 G T       FRANCE A7 a     Neerman-Arbez M et al. 2000  
 
   IVS4+1 G T       FRANCE A10 a     Neerman-Arbez M et al. 2000  
 
    IVS4+1 G T       FRANCE A11 a     Neerman-Arbez M et al. 2001  
 
   IVS4+1 G T       FRANCE B 1 a     Neerman-Arbez M et al. 2000    
 
    IVS4+1 G T       FRANCE B 11  a       Neerman-Arbez M et al. 2001   
 
    IVS4+1 G T   homozygous GRENOBLE, 2 cases a Yes No Polack B et al. 2010   
 
   
IVS4+1GT
  
compound
 KEOKUK
h
Yes
Yes
 Lefebve Pet al. 2004  
 
   IVS4+1 G T          UNITED STATES B 3 a     Neerman-Arbez M et al. 2000   
 
   IVS4+1 G T       UNITED STATES B 4 a       Neerman-Arbez M et al. 2000    
Aα(152)                                  
Aα(159)Arg stop  
CGA TGA
  
compound
 GEELONG
a
Yes
No
 Saravanan L et al. 2008    
 
Arg178X
g.3807C T
  
homozyg
 VENEZUELAN
a
Yes
 No Marchi-Cappelletti R et al. 2009    
Aα(162)Arg stop
Arg181X
c.541C T
  
homozyg
 PORTUGAL
a
Yes
     Neerman-Arbez M et al. 2007    
Aα(169)Leu
frameshiftstop
Leu188PhefsX4
c.563_564insT
  
homozyg
 COLUMBIA
a
Yes
     Neerman-Arbez M et al. 2007    
Aα(184) Glnstop
Gln203X
      
homozyg
 CHINESE 2
a
Yes
     Fang Y et al. 2006    
Aα(185) Leustop   3884_3885insTGA       R79
a
 Yes No    Monaldini L et al. 2005    
"
Leu204X
 g.3884_3885insTGA  
compound
 P2 ITALY (Palermo)
a
 Yes     Monaldini L et al. 2007    
Aα(193) Leustop
Leu212X
 c.635T G  
homozyg
 LEBANON (2 cas)
a
 Yes     Neerman-Arbez M et al. 2007    
Aα(219)Lysstop   3983 insT       ARNHEM
a
 Yes No Vlietman JJ et al. 2002  
Aα(221)Glnstop p.Q240X c.718C>T (CAG>TAG) e5 homozyg EGYPTIAN (n=6)
a
 Yes   Wahab A et al. 2010  
Aα(229)Trpstop
Trp248X
 c.743G A  
homozyg
 BULGARIA
a
 Yes   Neerman-Arbez M et al. 2007  
"
Trp248X
 g.4018G A  
homozyg
 P5 IRAN (Shiraz)
a
 Yes   Monaldini L et al. 2007  
 
p.Glu262fsX158
c.786_789 delGAGA
 e5
homozyg
 MOROCCO
a
Yes
   Robert-Ebadi H et al. 2009    
Aα(268)Gln-Glu-
Pro-stop		   4133insC       OTAGO h Yes No Ridgway H J et al. 1997  
Aα(272) ins 39aa   4146ins(117bp)       CHAMPAGNE AU MONT D'OR      No Yes Hanss M et al. 2001 A
Aα(276) Trpstop
Trp295X

c.885G A

 
homozyg
 ALGERIA
a
 Yes   Neerman-Arbez M et al. 2007  
Aα(291)
Aα(310)fsX
 4209delA       IRAN 2 a Yes No Asselta R et al. 2002  
 
   g.4110delA  
compound
   a Yes   Angles-Cano E et al. 2007  
 
  g.4179delA       B6, SWITZERLAND a Yes No Neerman-Arbez M et al. 2001  
 
(312)SerfsX42
c.934_935insA
  
homozyg
 CHINESE a     Xue F et al. 2009    
Aα(295)

Aα(314)
frameshift
stop

 4220delT       IRAN 3 a Yes No Asselta R et al. 2002  
"   g.4190delT       B5, TURKEY a     Neerman-Arbez M et al. 2001  
"   g.4190delT       C4, LEBANON a     Neerman-Arbez M et al. 2001  
Aα(297) Gly Stop G316X         FRANCE A7 a     Neerman-Arbez M et al. 2000  
Aα(315) Trp Stop W334X         FRANCE A12 a     Neerman-Arbez M et al. 2000  
" W334X g.g4277a  
homozyg
 TURKEY a
Yes
Yes
 Simsek I et al. 2008  
Aα(323) Gly
frameshift Stop		 Gly342GlufsX79
c.1025delG
  
homozyg
 TUNISIA a
Yes
   Neerman-Arbez M et al. 2007  
Aα(327)Asn
frameshift Stop		 Asn346ThrfsX75
c.1037delA
  
homozyg
 GERMANY a
Yes
   Neerman-Arbez M et al. 2007  
Aα(328) G1n Stop  
CAATAA
  
compound
 KEOKUK h
Yes
Yes
 Lefebvre P et al. 2004  
Aα(328) G1n Pro  
4315AC
  
heterozyg
 SEOUL II
 
   
Yes
 Park R et al. 2006  
Aα(333) Pro
frameshift stop		   4329delC       UNITED STATES B3 a       Neerman-Arbez M et al. 2000   
Aα(434)SerAsn           CARACAS II      No No Maekawa H et al. 1991  
Aα(439)ArgCys p.Arg458Cys g.4647C>T   heterozyg BORDEAUX      No Yes Hanss M et al. 2008  
Aα(452)Gly
Trp-Ser-Stop		    ATTATTT       MILANO III      No Yes Furlan M et al. 1994  
Aα(454) Asp Stop   CCTGATCCCTGA       NIEUWEGEIN      No No Collen A et al. 2001  
Aα(461)Lysstop   AAATAA       MARBURG h Yes Yes Koopman J et al. 1992
    
"   4713AT       GIESSEN h Yes No Nielssen A et al. 2002   A
Aα(465)Thr
Frameshift-12
aa-stop		   4727delC       WILMINGTON   Yes   Brennan SO et al. 2006  
Aα(467)Glustop   4731GT       CARACAS      Yes No Marchi R et al. 2001  
"   4731GT  
heterozyg
 GUARENAS      Yes     Marchi R et al. 2006  
Aα(476)Met4aa-stop   4758_4770del       LINCOLN      Yes No Brennan SO et al. 2002  
Aα(494)
frameshift stop		     4841delC       PERTH      Yes No Homer VM et al. 2003  
Aα494Hisframeshift23aa   C1537delA   heterozyg MANNHEIM V   No No Dempfle CE et al. 2009  
Aα(496)AspAsn D515N c.G1543A   heterozyg GRAND LYON III h     Hanss M et al. 2007  
"   c.1543G>A   compound MONTREAL h Yes No Campbell R et al. 2006  
Aα(499)Ala
frameshift stop		   1608de1C       SAN GIOVANNI ROTONDO      No No Margaglione M et al. 2001  
Aα(517-522)delins31aa-stop   1636_1650del,1649
_1650insCA 		      SEOUL m No No Kang HG et al. 2005  
Aα frame
shift522-548-stop		   4897del       PARIS VII m     Hamidi Asl L et al. 1997  
Aα frame
shift524-548-stop		   4904del       INDIANAPOLIS IV m     Uemichi T et al. 1996  
Aα(525)fs   c.1632delT  
heterozyg
 CHINESE m     Gillmore JD et al. 2009  
Aα(526)GluVal           CHRISTCHURCH IV      No No George PM et al. 1996 A
"   GAGGTG       INDIANAPOLIS II m No No Uemichi T et al. 1994  
"   GAGGTG       INDIANAPOLIS III m No No Uemichi T et al. 1996  
"   GAGGTG       LONDON IX          Gillmore JD et al. 2000  
"             AUSTRALIA m     Lane SW et al .2006  
"
(18 cases) 		           No AA amyloidosis
18 cases		 m     Lachmann HJ et al. 2002  
"      A T       PORTUGAL m       De Carvalho M et al. 2004  
"
(3 cases) 		  c.1577A>T   heterozyg GERMAN, 3 cases m     Eriksson M et al. 2008  
"       heterozyg MONTPELLIER m     Gahide G et al. 2008  
"
(46 cases) 		      heterozyg No AA amyloidosis 46 cases
 m     Gillmore JD et al. 2009  
"       heterozyg PORTUGUESE m     Delabre JP 2009 et al. 2009  
Aα(532)SerCys    TCTTGT       CARACAS V      No Yes Marchi R et al. 2000  
Aα(538)ThrLys   c.1670C>A   heterozyg CHINESE m     Gillmore JD et al. 2009  
Aα(540)GluVal   c.1676A>T   heterozyg GERMAN, 2 cases m     Gillmore JD et al. 2009  
Aα(552)ProHis   c.1712C>A   heterozyg CARIBBEAN m     Gillmore JD et al. 2009  
Aα(554)ArgCys           CHAPEL HILL III      No Yes Wada Y et al. 1994  
"   CGTTGT       DUSART / PARIS V      No Yes Koopman J et al. 1993  
"   CGTTGT       HANNOVER II      No Yes Meyer M et al 1999 A
"   CGTCTT       HANNOVER XI      No Yes Czwalinna A et al. 2001 A
"   CGTTGT       NASHVILLE      No Yes Tarumi T et al 2000  
Aα(554)ArgLeu   CGTCTT       INDIANAPOLIS m No No Benson MD et al. 1993  
"   CGTCTT       PARIS VIII m No No Hamidi Asl L et al. 1998  
"   CGTCTT       INDIANAPOLIS V m No No Uemichi T et al. 1998  
"           ENGLISH, 2 cases m     Gillmore JD et al. 2009  
Aa(554)ArgHis R573H GA e5 heterozyg SAN DIEGO V     Yes Morris TA et al. 2009  
Aα(559-625)delins72 578_644delins72 5011-5012delins10       GRAND LYON h Yes No Hanss M et al. 2005  
AαE(790)TyrCys   c.2425AG   compound MONTREAL h Yes No Campbell R et al. 2006  


NOTES :

  • Column 5 : "h" in case of hypofibrinogenaemia, "a" in case of afibrinogenaemia, “m” in case of amyloidosis
  • Column 8 : "A" in case of observation mentioned in a congress abstract, "L" in a book chapter, "O" for on-line submission
  • The first author of the team reporting the molecular abnormality is mentioned
  • 1 : post-partum DIC
  • 2 : antifibrinogen
  • Renal amyloidosis : Indianapolis, Indianapolis II, Indianapolis III, Indianapolis IV, Indianapolis V, Paris VII, Paris VIII. These abnormalities belong to the Aa 522-554 region


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